What You Should Know About Preimplantation Genetic Testing (PGT) During IVF

If you're considering or currently undergoing in vitro fertilization (IVF), you may have heard about preimplantation genetic testing, or PGT. This advanced form of genetic testing during IVF helps identify embryos with normal chromosomes before transferring, increasing the chance of a healthy pregnancy. But what exactly is PGT, who should consider it, and how does it fit into your IVF journey?

What Is Preimplantation Genetic Testing?

Preimplantation genetic testing (PGT) is a laboratory procedure performed during IVF to evaluate embryos for genetic abnormalities before they're transferred to the uterus. By analyzing a few cells from each embryo, fertility specialists in Florida can determine which embryos are most likely to result in a healthy pregnancy.

There are three types of PGT:

• PGT-A (for aneuploidy): Screens for abnormal chromosome numbers that may cause miscarriage or genetic conditions like Down syndrome.
• PGT-M (for monogenic/single gene disorders): Used when the parents are known carriers of conditions like cystic fibrosis or Tay-Sachs.
• PGT-SR (for structural rearrangements): Detects chromosome translocations and other structural issues that may hinder implantation.

Why Is Genetic Testing During IVF Becoming More Common?

Thanks to major advancements in genetics and embryo testing, PGT IVF is now a widely recommended option, especially for patients who:

• Are over 35
• Have experienced recurrent pregnancy loss
• Have had multiple failed IVF transfers
• Are carriers of inherited genetic conditions
• Want to reduce the risk of miscarriage
• Prefer elective single embryo transfer (eSET)

PGT-A in particular helps identify chromosomally normal embryos, increasing the chances of successful implantation and lowering the chance of early pregnancy loss.

How PGT Works During IVF

PGT is incorporated into the standard IVF process. After eggs are retrieved and fertilized, embryos are cultured in the lab for 5 to 7 days until they reach the blastocyst stage. Then:

1. A few cells are biopsied from the embryo’s outer layer (destined to become the placenta).
2. The embryo is frozen.
3. The sample is sent to a genetics lab for analysis.

Only embryos deemed genetically normal—or free from specific inherited conditions—are selected for transfer.

Is PGT IVF Right for Everyone?

Is preimplantation genetic testing necessary for all IVF patients? Not always.

Younger individuals with no fertility or genetic issues may not benefit from PGT-A, and cost may be a consideration. That’s why every fertility journey should begin with a personalized consultation.

PGT may be especially helpful if you:

• Are over 35
• Have had multiple failed transfers
• Have a personal or family history of genetic conditions
• Want to reduce the risk of miscarriage
• Are opting for a single embryo transfer (to avoid multiples)

Your care team will help determine if PGT IVF is appropriate for your specific goals.

Considerations and Limitations of Preimplantation Genetic Testing

Although PGT offers valuable insights, it's not a guarantee of a successful pregnancy. Embryos must still implant and develop normally after transfer.

What are the limitations of PGT IVF?

• A small risk of embryo damage during biopsy (though greatly reduced with modern techniques)
• Possible mosaic results (embryos with both normal and abnormal cells), which require nuanced decisions
• Inconclusive results in rare cases
• It does not detect all genetic or developmental conditions

Prenatal testing, such as noninvasive prenatal testing (NIPT) or amniocentesis, is still recommended during pregnancy.

Should I speak with a genetic counselor before undergoing PGT?

Yes. Genetic counseling is a vital part of the process. A certified counselor will explain the scope and limitations of testing, help you understand possible results, and support you through emotionally complex decisions, especially if you’re at risk for passing on an inherited condition.

Making Informed Choices with PGT IVF

As more individuals and couples pursue IVF, preimplantation genetic testing offers a powerful tool for making informed decisions. At Palm Beach Fertility Center, we incorporate PGT IVF as part of a holistic fertility treatment strategy, balancing advanced technology with personalized, compassionate care.

Whether you're exploring IVF for the first time or considering genetic testing during IVF due to personal or family history, we’re here to guide you.

FAQs About Preimplantation Genetic Testing (PGT)

What is the purpose of PGT in IVF?

PGT identifies embryos with normal chromosomes or those unaffected by inherited conditions, which improves implantation success and reduces miscarriage risk.

Who should consider PGT?

PGT is recommended for those over 35, with a history of miscarriage or failed IVF, or who are carriers of genetic disorders.

Is PGT safe for embryos?

While there is a small risk during the biopsy, modern techniques are safe and widely used in leading fertility clinics.

Will PGT detect all genetic problems?

No. PGT is limited to certain conditions and chromosomal issues. Prenatal testing is still recommended during pregnancy.

Take the Next Step with Confidence

At Palm Beach Fertility Center, our Palm Beach fertility specialist provide advanced preimplantation genetic testing (PGT) services as part of a comprehensive IVF program. From lab diagnostics to genetic counseling, our fertility team guides you through each step with clarity and care.

Schedule your PGT IVF consultation in Palm Beach today. Call (888) 819-5177 or explore our IVF services to get started on your journey to parenthood.